Mussel-inspired hydrogel with injectable self-healing and antibacterial properties promotes wound healing in burn wound infection

Abstract Burn wound infections cause serious problems for public health. More than 180,000 patients die from burns every year worldwide. In addition, the difficulty of healing wounds and caused by affects mental health patients. Therefore, it is very important to develop a dressing that can promote repair exhibits good antibacterial effects. Here, we used oxidized konjac glucomannan (OKGM), γ-poly(glutamic acid) modified with dopamine L -cysteine (γ-PGA-DA-Cys) ε-polylysine (ε-PL) produce an OKGM/γ-PGA-DA-Cys/ε-PL (OKPP) hydrogel. This hydrogel was produced thiol-aldehyde addition Schiff-base reactions has ability be injected self-heal. The results showed effects on Pseudomonas aeruginosa Staphylococcus aureus antioxidant in vitro. Moreover, also adhesion. burn infection model, promoted reduced production inflammation. These proved clinical potential as infection.